Richard C.K. Jordan

Laser capture microdisection of oral mucosa The focus of my translational research program has been the characterization of molecular events that occur during the progression of oral precancer to oral cancer and if these changes can be used to predict oral cancer development. My group was the first to characterize changes in critical cell cycle regulators including p27kip1 and skp2 in oral precancer and cancer. We were also the first to show differing patterns of p53 protein expression in oral precancer and to fully describe changes in the entire p53 gene in head and neck cancers and their impact on radiation therapy. We have also characterized alterations in the CDKN2A gene and p14ARF in oral precancer and cancer. We use many state-of-the-art molecular pathology methods including laser capture microdissection (LCM) to harvest tumor cells, cDNA microarrays to analyze global gene expression and real-time, and TaqMan PCR to analyze mRNA in routinely processed tissue sections.

As part of the UCSF Oral Cancer Program Project, I am directing the Tissue Bank and Pathology Core that provides fundemental support for the oral cancer research projects. The Core represents a network of clinicians, pathologists, and technical staff whose aims are, 1) to collect, identify, and make available to researchers, human oral cancerous tissues, 2) to develop a patient data-base for correlation of patient outcome with molecular tumor markers, and 3) to collaborate with the Program investigators relative to histopathology and immunohistochemistry.

Darren P. Cox Coming soon!

Troy E. Daniels

Sjögrens syndrome, parotid gland My principal research interests are in studying the salivary gland pathology of the autoimmune disease Sjögren's syndrome (SS) and the clinical diagnosis and oral sequelae of that chronic and complex disease. I have actively participated in developing international criteria for diagnosing SS for several years. With contributions from colleagues, I have developed comprehensive clinical guidelines for oral treatment and dental caries prevention in patients with SS (and other causes of chronic dry mouth), which have been adopted by the national patient support group for SS patients and widely distributed internationally. I also continue to be interested in the diagnostic applications of direct immunofluorescence microscopy to diagnosing chronic inflammatory mucosal diseases.

John S. Greenspan

Hairy leukoplakia, tongue My research interests center on the etiology, pathogenesis, epidemiology, and management of oral soft tissue diseases, notably those associated with HIV infection and other causes of immunosuppression, as well as aphthous ulcers, Sjögren's syndrome , and oral cancer/precancer. My long-term goal is to understand these diseases in order to prevent and treat them. My group has been responsible for major portions of the growing body of information on oral aspects of AIDS, including the discovery of hairy leukoplakia and its causation by the Epstein-Barr virus , the significance of that lesion and of oral candidiasis as predictors of progression of HIV disease, and the apparently protective effects of salivary gland disease in the HIV-infected population. My work has spanned the spectrum from molecular biology and electron microscopy cytochemistry, through clinical epidemiology and therapeutic trials, to public health and policy issues. I have been fortunate to see much of this work applied in the mainstream of AIDS science, care, and policy.

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